Fluorescent aptasensor based on aggregation-induced emission probe and carbon nanomaterials

Abstract

Fluorescent biosensors have received great attention because of their high sensitivity, rapid and easy operations. Recently, fluorescent probes with aggregation-induced emission (AIE) feature provide a new approach for label-free and turn-on fluorescent analysis assay, due to their unique luminescent characteristics. Here, we summarized the recent progress of fluorescent aptasensor for biomolecules based on the integration of AIE probe and carbon nanomaterials. The introduction of carbon nanomaterials can not only enhance the sensitivity, but also improve the selectivity for biomolecules. Through optimizing the supramolecular interactions of AIE probes and carbon nanomaterials with biomolecules, the detection limitation can reach as low as 0.17 nM for detecting the target DNA sequence. It is believed that the research efforts will provide an efficient approach to improve the performance of biomolecules sensing assay and an in-depth understanding of the supramolecular interactions of AIE probes and carbon nanomaterials with biomolecules, and thus facilitate their extended applications in biosensors and biomedicine.