Exploring the vast number of possible feature interactions in domains such as gene expression microarray data is an onerous task. We propose Backward-Chaining Rule Induction (BCRI) as a semi-supervised mechanism for biasing the search for plausible feature interactions. BCRI adds to a relatively limited tool-chest of hypothesis generation software, and it can be viewed as an alternative to purely unsupervised association rule learning. We illustrate BCRI by using it to search for gene-to-gene causal mechanisms. Mapping hypothesized gene interactions against a domain theory of prior knowledge offers support and explanations for hypothesized interactions, and suggests gaps in the current domain theory, which induction might help fill. © Springer-Verlag Berlin Heidelberg 2005.
CITATION STYLE
Fisher, D., Edgerton, M., Tang, L., Frey, L., & Chen, Z. (2005). Searching for meaningful feature interactions with backward-chaining rule induction. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 3646 LNCS, pp. 86–96). Springer Verlag. https://doi.org/10.1007/11552253_9
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