Cororubicin, a new anthracycline antibiotic generating active oxygen in tumor cells

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Abstract

In the course of our screening for antitumor antibiotics which show biological activities by generating active oxygen in tumor cells, Micromonospora sp. JY16 was found to produce a new anthracycline antibiotic designated cororubicin. The structure of cororubicin was elucidated as shown in Fig. 5 on the basis of NMR spectral analysis. Cororubicin generated superoxide radicals in tumor cells and showed cytotoxicity, which was reduced by addition of an antioxidative agent, dithiothreitol (DTT). © 1994, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Ishigami, K., Hayakawa, Y., & Seto, H. (1994). Cororubicin, a new anthracycline antibiotic generating active oxygen in tumor cells. The Journal of Antibiotics, 47(11), 1219–1225. https://doi.org/10.7164/antibiotics.47.1219

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