Generation of Pd nanoparticles in situ from PdCl2 in TBAF: An efficient and reusable catalytic system for the suzuki-miyaura reaction under ligand- and solvent-free conditions

Abstract

Pd nanoparticles were generated in situ from PdCl2 in TBAF (n-Bu4NF), which displayed high efficiency for the Suzuki-Miyaura cross-coupling reaction. In the presence of PdCl2 and TBAF, a variety of aryl halides were coupled with arylboronic acids smoothly in moderate to good yields. Moreover, the PdCl2/TBAF system could be recovered and reused several times in the Suzuki-Miyaura reaction, and aryl bromides could be consumed completely by arylboronic acids in about 15-60 min. It is noteworthy that these reactions were conducted under solvent-free, ligand-free and reusable conditions. Mechanism for the PdCl2/TBAF-catalyzed reactions was also discussed. © 2009 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.