Tetrabutylammonium iodide-catalyzed radical alkoxycarbonylation of 2-isocyanobiphenyls with carbazates: Synthesis of phenanthridine-6-carboxylates

Abstract

A practical and environmentally friendly strategy for generating alkoxycarbonyl radicals from readily available carbazates under metal-free conditions has been developed. In the presence of tetrabutylammonium iodide and tert-butyl hydroperoxide, 2-isocyanobiphenyls smoothly underwent radical alkoxycarbonylation with carbazates to afford phenanthridine-6-carboxylates. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.