Synthesized and release study of labelled small mesoporous silica nanoparticle as theranostic material

Abstract

Combination of diagnosis and therapy, which is called theranostic, became great concern to treat cancer. Mesoporous silica nanoparticle (MSN) has several features, such as high surface area, biocompatible, and non-toxic, which support as potential theranostic materials. In this study, we have successfully synthesized small MSN and modification by addition of imaging agent. The small particle size and porosity were beneficial for its high colloidal stability and high surface area to accommodate drugs. Labelled small MSN (LMSN) can emit the energy which will be useful for diagnosis matter. In addition, we functionalized LMSN by polyelectrolyte addition to increase its sensitivity. The drug released showed that functionalization on the surface produced more sensitive drug release profile which is triggered by pH.