Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy. © 2006 BioMed Central Ltd.
CITATION STYLE
Beresford, M. J., Wilson, G. D., & Makris, A. (2006, November 30). Measuring proliferation in breast cancer: Practicalities and applications. Breast Cancer Research. https://doi.org/10.1186/bcr1618
Mendeley helps you to discover research relevant for your work.