Immunohistochemical expression of cycloxygenase-2 in astrocytoma: Correlation with angiogenesis, tumor progression and survival

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Abstract

Aim: Cyclooxygenase-2 (Cox-2) appears to play a role in the regulation of progression, invasiveness and angiogenesis of various neoplasms. Experimental studies have indicated that COX-2 regulate angiogenesis by modulating vascular endothelial growth factor (VEGF) production. The aim of this study was to evaluate the immunohistochemical expression of COX-2 in astrocytoma, in relation to VEGF expression, microvessel density (MVD), clinicopathologic factors and patient survival. Material and Methods: 26 paraffin blocks of astrocytoma, with representative tissues and sufficient follow-up data, were evaluated immunohistochemically for protein marker expression. Results: COX-2 expression was detected in 21 (80.7%) of 26 astrocytomas with an increased expression in grade IV (100%) as compared to grades II (63.6%) and III (83.3%) (p<0.001), (r=0.64). A positive correlation was observed between the immunoreactive scores of COX-2, VEGF (p<0.001), (r=0.61) and MVD (p<0.001), (r=0.72). Also COX-2 expression was significantly associated with poor survival (p< 0.001), (r=0.58), but did not show significant difference among patient age, sex and tumor location. Conclusion: COX-2 is up-regulated in the majority of high-grade astrocytomas and may contribute to astrocytic tumorigenesis by promoting new vessel formation. Moreover, increased COX-2 expression is a significant negative predictor of survival. COX-2 inhibitors may represent an important therapeutic target.

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El-Sayed, M., & Taha, M. M. (2011). Immunohistochemical expression of cycloxygenase-2 in astrocytoma: Correlation with angiogenesis, tumor progression and survival. Turkish Neurosurgery, 21(1), 27–35. https://doi.org/10.5137/1019-5149.jtn.3354-10.1

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