A disturbed epidermal barrier may lead to irritant contact dermatitis. An enhanced penetration through skin barrier may facilitate sensitization. Immunological effects induced by pre-irritation and barrier alteration may further lead to the induction of allergic Typ IV-contact dermatitis and Type I (immediate-type reaction) reactions or aggravate allergic reactions.
CITATION STYLE
Rustemeyer, T., & Fartasch, M. (2012). Immunology and barrier function of the skin. In Kanerva’s Occupational Dermatology, Second Edition (Vol. 1, pp. 3–8). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-02035-3_1
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