Liver Injury Assessment by Vetscan VS2 Analyzer and Most Frequently Used ALT/GTP Reagent

Abstract

analyzer can measure ALT up to 2000 U/L and there is no need to perform serum dilutions. The goal of this study was to determine the accuracy of the results generated from VetScan VS2 analyzer compared to the standard ALT/GPT Stable Liquid Reagent. We used two animal models with differing degrees of liver injury. In the first model, we fed mice a high fat containing diet, which leads to mild hepatic steatosis (lipid accumulation in the liver), but no liver injury. For the second model, we selected a hepatotoxin, carbon tetrachloride (CCl 4), to induce liver injury, which leads to severe liver damage and hepatic fibrosis [7].