In 1978, Nozaki, Oshima, and Takai reported that CH2X 2 -Zn-TiCl4 reagent is effective for Wittig-type methylenation of carbonyl compounds. We investigated this reagent system in detail and concluded that CH2(ZnI)2 and β-TiCl 3 are real reactive species. Chemoselective methylention using dizinc reagent is also shown.
CITATION STYLE
Matsubara, S. (2007). Transition of methylenation reaction- The outcome of “ingredients of couldron.” Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 65(3), 194–203. https://doi.org/10.5059/yukigoseikyokaishi.65.194
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