Immunoevasion is a hallmark of cancer progression, and immune checkpoint blockade has emerged as a promising strategy for cancer treatment. microRNAs (miRNAs) are important negative regulators of gene expression in the immune system. Here, we demonstrate that miR-708 regulates CD47, a transmembrane protein that inhibits phagocytosis in T cell acute lymphoblastic leukemia. miR-708 directly targeted CD47 through binding to 3'UTR and is inversely correlated with CD47 expression. Functional studies showed that restoration of miR-708 expression in the T-ALL cell line is sufficient to promote phagocytosis by macrophages in the absence or presence of the anti-CD47 antibody to eradicate T-ALL cells, and inhibited tumor engraftment in vivo. Together, our findings suggest that miR-708 is a key negative regulator of CD47 and may serve as an attractive candidate for immunotherapy of T-ALL.
CITATION STYLE
Huang, W., Wang, W. T., Fang, K., Chen, Z. H., Sun, Y. M., Han, C., … Chen, Y. Q. (2018, January 24). MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47. Molecular Cancer. BioMed Central Ltd. https://doi.org/10.1186/s12943-018-0768-2
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