Potassium Dehydroandrographolide Succinate and Potassium Sodium Dehydroandrographolide Succinate

Abstract

Potassium dehydroandrographolide succinate and potassium sodium dehydroandrographolide succinate are derivatives of andrographolide, which is the diterpene lactone compounds extracted from Andrographis paniculata (Burm. F) Nees. Andrographolide has effects on anti-inflammatory, antibacterial, antivirus, antitumor, immune regulation, treatment of cardiovascular-cerebrovascular diseases, and protection of liver and gallbladder but is unable to satisfy the clinical requirement due to the poor water solubility. Potassium dehydroandrographolide succinate and potassium sodium dehydroandrographolide succinate have a good effect in the wide clinical application; there is no need for skin test. However adverse reaction occurs due to its instability in the solution. Therefore, the researchers still need to study and develop preparation which is more safe, reliable, stable, and convenient to use to meet the clinical requirements.