Midazolam Inhibits Tumor Necrosis Factor-α–induced Endothelial Activation

Abstract

The article explores the activity of midazolan on endothelial activation and its role to peripheral benzodiazepine receptor in cultured human umbilical vein endothelial cells. Monocyte adhesion assay and Western blot analysis were used to measure monocyte adhesion and vascular cell adhesion molecule-1 expression. It reveals that mitochondria play a key role in cell function by regulating adenosine triphosphate production and induction of cell death. It suggests that midazolam plays an antiinflammatory action in vascular endothelial activation.