Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697

82Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

New antimalarial drugs are urgently needed. The use of short courses of the new antimalarial drug artemether as monotherapy has been limited by secondary malaria episodes following parasite clearance. Therefore, a new antimalarial drug, CGP 56697, has been developed, which combines artemether with a longer-acting antimalarial agent benflumetol. A safety trial was undertaken in 60 Gambian children 1-6 years old with uncomplicated Plasmodium falciparum malaria. All children treated with CGP 56697 cleared their parasites 72 h after the start of treatment. No neurologic, cardiac, or other adverse reactions were observed. Second episodes of falciparum malaria were recorded in 16 (27%) of the children. Second infections were more frequent during the rainy season than during the dry season. Molecular epidemiologic studies suggested that 12 of the 14 second episodes of malaria in children treated with CGP 56697 were due to new infections. CGP 56697 proved to be a safe and effective antimalarial drug in African children.

Cite

CITATION STYLE

APA

Von Seidlein, L., Jaffar, S., Pinder, M., Haywood, M., Snounou, G., Gemperli, B., … Greenwood, B. (1997). Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697. Journal of Infectious Diseases, 176(4), 1113–1116. https://doi.org/10.1086/516524

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free