Quantitative analysis of the spatial organization of synaptic inputs on the postsynaptic dendrite

0Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

The spatial organization of synaptic inputs on the dendritic tree of cortical neurons is considered to play an important role in the dendritic integration of synaptic activity. Active electrical properties of dendrites and mechanisms of dendritic integration have been studied for a long time. New technological developments are now enabling the characterization of the spatial organization of synaptic inputs on dendrites. However, quantitative methods for the analysis of such data are lacking. In order to place cluster parameters into the framework of dendritic integration and synaptic summation, these parameters need to be assessed rigorously in a quantitative manner. Here I present an approach for the analysis of synaptic input clusters on the dendritic tree that is based on combinatorial analysis of the likelihoods to observe specific input arrangements. This approach is superior to the commonly applied analysis of nearest neighbor distances between synaptic inputs comparing their distribution to simulations with randomreshuffling or bootstrapping. First, the new approach yields exact likelihood values rather than approximate numbers obtained from simulations. Second and more importantly, the newapproach identifies individual clusters and thereby allows to quantify and characterize individual cluster properties.

References Powered by Scopus

Neocortical excitation/inhibition balance in information processing and social dysfunction

1846Citations
N/AReaders
Get full text

Network neuroscience

1575Citations
N/AReaders
Get full text

Independent optical excitation of distinct neural populations

1530Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Scheuss, V. (2018). Quantitative analysis of the spatial organization of synaptic inputs on the postsynaptic dendrite. Frontiers in Neural Circuits, 12. https://doi.org/10.3389/fncir.2018.00039

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

54%

Professor / Associate Prof. 3

23%

Researcher 3

23%

Readers' Discipline

Tooltip

Neuroscience 6

46%

Agricultural and Biological Sciences 5

38%

Social Sciences 1

8%

Earth and Planetary Sciences 1

8%

Save time finding and organizing research with Mendeley

Sign up for free