This chapter describes the basic protocols for solid-phase peptide synthesis using the Fmoc group as the Nα -protecting group (Fmoc-SPPS). The chapter introduces resins and their handling, choice of linkers, and the most common methods for peptide chain assembly. The proper choice of resins and linkers for solid-phase synthesis is a key parameter for successful peptide synthesis. This chapter provides an overview of the most common and useful resins and linkers for the synthesis of peptides with C-terminal amides, carboxylic acids, and more. The chapter finishes with robust protocols for general solid-phase peptide synthesis, i.e., the standard operations.
CITATION STYLE
Shelton, P. T., & Jensen, K. J. (2013). Peptide Synthesis and Applications: Linkers, Resins, and General Procedures for SPPS. Peptide Synthesis and Applications, 1047, 23–41. Retrieved from http://link.springer.com/10.1007/978-1-62703-544-6
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