Tetherin (BST2/CD317) has emerged as a key host cell defense molecule, inhibiting the release and spread of diverse enveloped virions from infected cells. In this chapter, I review the molecular and cellular basis for tetherin's antiviral activities and the function of virally encoded countermeasures that disrupt its function. I further describe recent advances in our understanding of tetherin's associated role in viral pattern recognition and the evidence for its role in limiting viral pathogenesis in vivo. © 2013 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Neil, S. J. D. (2013). The antiviral activities of tetherin. Current Topics in Microbiology and Immunology, 371, 67–104. https://doi.org/10.1007/978-3-642-37765-5_3
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