Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

83Citations
Citations of this article
120Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is metabolic diseases, which affect people of all ages and usually manifest their pathobiology through life-threatening cardiovascular complications. A comprehensive understanding of the pathobiology of metabolic diseases will generate novel targets for improved therapies across the common metabolic spectrum. Protein posttranslational modification (PTM) is an important term that refers to biochemical modification of specific amino acid residues in target proteins, which immensely increases the functional diversity of the proteome. The range of PTMs includes phosphorylation, acetylation, methylation, ubiquitination, SUMOylation, neddylation, glycosylation, palmitoylation, myristoylation, prenylation, cholesterylation, glutathionylation, S-nitrosylation, sulfhydration, citrullination, ADP ribosylation, and several novel PTMs. Here, we offer a comprehensive review of PTMs and their roles in common metabolic diseases and pathological consequences, including diabetes, obesity, fatty liver diseases, hyperlipidemia, and atherosclerosis. Building upon this framework, we afford a through description of proteins and pathways involved in metabolic diseases by focusing on PTM-based protein modifications, showcase the pharmaceutical intervention of PTMs in preclinical studies and clinical trials, and offer future perspectives. Fundamental research defining the mechanisms whereby PTMs of proteins regulate metabolic diseases will open new avenues for therapeutic intervention.

References Powered by Scopus

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study

6492Citations
N/AReaders
Get full text

Health effects of overweight and obesity in 195 countries over 25 years

5588Citations
N/AReaders
Get full text

Protein kinases - The major drug targets of the twenty-first century?

1994Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

75Citations
N/AReaders
Get full text

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

65Citations
N/AReaders
Get full text

Mechanisms and functions of protein S-acylation

33Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Wu, X., Xu, M., Geng, M., Chen, S., Little, P. J., Xu, S., & Weng, J. (2023, December 1). Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies. Signal Transduction and Targeted Therapy. Springer Nature. https://doi.org/10.1038/s41392-023-01439-y

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 28

65%

Researcher 8

19%

Professor / Associate Prof. 6

14%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 17

49%

Agricultural and Biological Sciences 8

23%

Immunology and Microbiology 6

17%

Pharmacology, Toxicology and Pharmaceut... 4

11%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free