The precise elucidation of the gene concept has become the subject of intense discussion in light of results from several, large high-throughput surveys of transcriptomes and proteomes. In previous work, we proposed an approach for constructing gene concepts that combines genomic heritability with elements of function. Here, we introduce a definition of the gene within a computational framework of cellular interactions. The definition seeks to satisfy the practical requirements imposed by annotation, capture logical aspects of regulation, and encompass the evolutionary property of homology.
CITATION STYLE
Stadler, P. F., Prohaska, S. J., Forst, C. V., & Krakauer, D. C. (2009). Defining genes: A computational framework. Theory in Biosciences, 128(3 SPECIAL ISSUE), 165–170. https://doi.org/10.1007/s12064-009-0067-y
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