Abstract
In this chapter, we will review the epidemiology, clinical phenotype, genetics, causes, and management of amyotrophic lateral sclerosis (ALS). ALS is a devastating and invariably fatal adult-onset neurodegenerative disorder. It remains incurable, killing about 1,200 people in the UK each year. It has an annual incidence of 1-2 per 100,000, a figure that appears to be consistent in most populations studied around the world. ALS is also known as Lou Gehrig's disease in the USA and motor neuron disease (MND) in the UK.
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CITATION STYLE
Leigh, P. N., Sreedharan, J., & Wijesekera, L. (2013). Motor neuron disease: Amyotrophic lateral sclerosis. In Neuroscience in the 21st Century: From Basic to Clinical (pp. 2861–2902). Springer New York. https://doi.org/10.1007/978-1-4614-1997-6_111
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