Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is remarkably heterogeneous at the clinical, neurobiological, and genetic levels. ASD can also affect language, a uniquely human capability, and is caused by abnormalities in brain development. Traditionally obtaining biologically relevant human cells to study ASD has been extremely difficult, but new technologies including iPSC-derived neurons and high-throughput omic techniques now provide new, exciting tools to uncover the cellular and signaling basis of ASD etiology.
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Turkalj, L., Mehta, M., Matteson, P., Prem, S., Williams, M., Connacher, R. J., … Millonig, J. H. (2020). Using iPSC-Based Models to Understand the Signaling and Cellular Phenotypes in Idiopathic Autism and 16p11.2 Derived Neurons. In Advances in Neurobiology (Vol. 25, pp. 79–107). Springer. https://doi.org/10.1007/978-3-030-45493-7_4
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