Glomerular filtration rate is related to severity of obstructive coronary artery disease in patients undergoing coronary angiography

Abstract

Purpose Chronic kidney disease is independently associated with an increased risk of cardiovascular events; however, the relationship between the glomerular filtration rate (GFR) and coronary artery disease (CAD) in patients undergoing coronary angiography has yet to be fully elucidated. Methods: This retrospective study enrolled a total of 7968 patients who underwent diagnostic coronary artery catheterization [mean age = 54.8 ± 10.6 years, 74.4% males] and did not have any previous history of coronary revascularization, diabetes mellitus, hypertension, end-stage renal disease treated by dialysis or renal transplantation, and were not taking diuretics or drugs acting on renin angiotensin system. The severity of CAD was defined as the number of coronary arteries with a luminal stenosis ≥50% on the angiogram, and the GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Results: There were 2133 (26.8%) patients with GFR ≥ 90 ml/min/1.73 m2, 4574 (57.4%) patients with 60 ≤ GFR<90 ml/min/1.73 m2, 1073 (13.5%) with 45 ≤ GFR<60 ml/min/1.73 m2 and 181 (2.3%) with 15 <90 ml/min/1.73 m2 to 1.8 in patients with 15