Synthesis, characterization and antitumor activity of the germanium-quercetin complex

Abstract

Quercetin-germanium (Ge) (IV) complex was synthesized in the laboratory. The structure and physicochemical properties of the complex were characteri zed utilizing thermal and spectroscopic (UV-vis, IR and 1H NMR) analysis. The antitumor activity of quercetin-Ge (IV) compound was evaluated by the MTT method. The complex was subjected to biological tests in vitro using four tumor cell lines (PC-3, Hela, EC9706 and SPC-A-1). The quercetin-Ge (IV) complex showed significant cytotoxicity against four tumor cell lines. © 2012 by Walter de Gruyter • Berlin • Boston.