Cannibalistic viruses in the aquatic environment: role of virophages in manipulating microbial communities

Abstract

The ecological role of viruses in aquatic environments is gaining interest due to their abundance and overall diversity. Much focus has been on bacteriophages since they were found to play an important role in the diversification and sustainment at both the micro- and macro-scale. However, the discovery of virophages coexisting with giant viruses in a diverse set of eukaryotic hosts has recently gained attention. Virophages are small double-stranded DNA viruses found parasitizing giant viruses of eukaryotes. Since the discovery of the first virophage (Sputnik) many virophage signatures have been detected from a variety of environmental samples with specific infection cycles. In addition, these parasites display important roles in equilibrating microbial biomass, nutrient cycling and population dynamics. Moreover, virophage-induced evolution between giant viruses and their hosts have also been described. Considering the ongoing discovery of virophages and their dynamics in aquatic ecosystems, this review intends to provide an update of the virophage signatures identified to date, also tending to provide insight on the mechanisms of coinfection as well as their role as agents of biodiversity and nutrient cyclers in water environments.