Catalytic Antibodies for Organic Synthesis

Abstract

A review with 112 refs. Monoclonal antibodies with strong binding affinities tailored to any mol. target can be produced from immunized mice using hybridoma technol. Due to their directable binding specificities and ease of prepn., monoclonal antibodies are used in the daily practice of biol. research as well as in many diagnostic applications. Since 1986 monoclonal antibodies with catalytic properties have been prepd. by immunizing mice with stable transition state analogs of chem. reactions, thereby providing a versatile source of novel biocatalysts. This review discusses catalytic antibodies with respect to org. synthetic reactions