A synthesis of 6-deoxy-6-fluorosucrose suitable for PET applications

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Abstract

A new route to 6-deoxy-6-fluorosucrose has been developed. The process proceeds in 8 linear steps in 25% overall yield from sucrose. The steps incorporating fluorine and subsequent deprotection are quite rapid, making the procedure useful in the context of 18F-labeling for PET applications.

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Gao, X., Gaddam, V., & Harmata, M. (2014). A synthesis of 6-deoxy-6-fluorosucrose suitable for PET applications. Carbohydrate Research, 400, 14–18. https://doi.org/10.1016/j.carres.2014.08.015

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