Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles

Abstract

Background: SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. Aim of the study: To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. Methods: SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. Results: Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. Conclusion: Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.