Microvessel Remodeling in Cerebral Ischemia

Abstract

It is now known that the adult mammalian brain undergoes repair and renewal from pools of stem cells and that cell cycle alteration may cause a variety of neurological disorders ranging from autism to brain tumors. In The Cell Cycle in the Central Nervous System, prominent researchers, physicians, engineers, and pharmacologists join forces to delineate how the brain is a complex organ composed of widely varying cell types, including blood vessels, and what its cellular-based disorders may be. Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system (CNS) to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle. State-of-the-art and readily understandable, The Cell Cycle in the Central Nervous System illuminates our understanding of how brain development, disease, renewal, and repair may be mediated by vasculogenesis, neurogenesis, and the immune system, and offers an exciting variety of new research opportunities for all those investigating brain tumors, neurodevelopment, and neurological disorders. Methodological considerations in the evaluation of cell cycle in the central nervous system / Richard A. Prayson -- Neural stem cells / Philippe Taupin -- Progenitors and precursors of neurons and glial cells / Monika Bradl -- Vaculogenesis and angiogenesis / Gerald A. Grant and Damir Janigro -- Neuronal migration and malformation of cortical development / Giorgio Battaglia and Stefania Bassanini -- Genome-wide expression profiling of neurogenesis in relation to cell cycle exit / P. Roy Walker [and others] -- Neurogenesis and apoptotic cell death / Klaus van Leyen [and others] -- Ion channels and cell cycle / Annarosa Arcangeli and Andrea Becchetti -- Nonsynaptic GABAergic communication and postnatal neurogenesis / Xiuxin Liu, Anna Bolteus, and Angélique Bordey -- Critical roles of Ca2+ and K+ homeostasis in apoptosis / Shan Ping Yu -- Mammalian neural stem-cell renewal / Yvan Arsenijevic -- Methods of determining apoptosis in neuro-oncology: review of the literature / Brian T. Ragel [and others] -- Cell cycle, neurological disorders, and reactive gliosis / Kerri L. Hallene and Damir Janigro -- Potassium channels, cell cycle and tumorigenesis in the central nervous system / Gabriele Dini, Erin V. Ilkanich, and Damir Janigro -- Enhanced neurogenesis following neurological disease / Philippe Taupin -- Endothelial injury and cell cycle re-entry / Ljiliana Krizanac-Bengez -- The contribution of bone marrow-derived cells to cerebrovascular formation and integrity / David Kobiler and John Glod -- Microvessel remodeling in cerebral ischemia / Danica B. Stanimirovic, Maria J. Moreno, and Arsalan S. Haqqani -- Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders / Lieve Moons, Peter Carmeliet, and Mieke Dewerchin -- Epidermal growth factor receptor in the adult brain / Carmen Estrada and Antonio Villalobo -- Neurodegeneration and loss of cell cycle control in postmitotic neurons / Randall D. York, Samantha A. Cicero, and Karl Herrup -- Cell cycle activation and the amyloid-[beta] protein in Alzheimer's disease / Katarzyna A. Gustaw [and others] -- Neuronal precursor proliferation and epileptic malformations of cortical development / Jorge A González-Martínez, William E. Bingaman, and Imad M. Najm -- Vascular differentiation and cell cycle / Luca Cucullo -- Adult neurogenesis and central nervous system cell cycle analysis: novel tools for exploration of the neural causes and correlates of psychiatric disorders / Amelia J. Eisch and Chitra D. Mandyam -- Neurogenesis and Alzheimer's disease: compensation, crisis, or chaos? / Gemma Casadesus [and others] -- P53 and multidrug resistance transporters in the central nervous system / Shirley Teng and Micheline Piquette-Miller -- Signaling modules in glial tumors and implications for molecular therapy / Gurpreet S. Kapoor and Donald M. O'Rourke -- Detection of proliferation in gliomas by positron emission tomography imaging / Alexander M. Spence [and others] -- Transition of normal astrocytes into a tumor phenotype / Sean E. Aeder and Isa M. Hussaini -- Mechanisms of gliomagenesis / Wei Zhang and Howard A. Fine -- Cell cycle of encapsulated cells / Roberto Dal Toso and Sara Bonsiegna -- Viral vector delivery to dividing cells / Yoshinaga Saeki -- Electrical stimulation and angiogenesis: electrical signals have direct effects on endothelial cells / Min Zhao -- Development and potential therapeutic aspects of mammalian neural stem cells / L. Bai, S.L. Gerson, and R.H. Miller -- Mammalian Sir2 proteins: a role in epilepsy and ischemia / Barbara Aumayr and Damir Janigro.