ARH GEF17 sets the timer for retention of Mps1 at kinetochores

Abstract

The kinetochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its kinetochore recruitment and activity is unclear. In this issue, Isokane et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201408089) show that interaction with and phosphorylation of its substrate, ARH GEF17, regulates Mps1 kinetochore retention, suggesting an autoregulated, timer-like mechanism.