Non-hodgkin lymphoma metabolism

Abstract

Aggressive lymphomas exhibit the Warburg effect.Lactic acidosis is a result of overproduction of lactate and leads to a fatal prognosis.Mutation of p53 helps cancer cells survive glutamine deprivation.PI3K regulates fatty acid synthesis (FAS) in primary effusion lymphoma (PEL) and other B-NHLs.AMPK regulates NADPH balance for fatty acid oxidation as a means of supplementing the TCA cycle.PRPS2 couples protein and nucleotide biosynthesis to drive lymphomagenesis.mTOR activation promotes fatty acid synthesis (FAS).MYC regulates cancer cell metabolism under glucose-deprived and hypoxic conditions.HIF-1 acts as a regulator in hypoxia adaption and the related metabolic change.