Non-hodgkin lymphoma metabolism

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Abstract

Aggressive lymphomas exhibit the Warburg effect.Lactic acidosis is a result of overproduction of lactate and leads to a fatal prognosis.Mutation of p53 helps cancer cells survive glutamine deprivation.PI3K regulates fatty acid synthesis (FAS) in primary effusion lymphoma (PEL) and other B-NHLs.AMPK regulates NADPH balance for fatty acid oxidation as a means of supplementing the TCA cycle.PRPS2 couples protein and nucleotide biosynthesis to drive lymphomagenesis.mTOR activation promotes fatty acid synthesis (FAS).MYC regulates cancer cell metabolism under glucose-deprived and hypoxic conditions.HIF-1 acts as a regulator in hypoxia adaption and the related metabolic change.

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Kirsch, B. J., Chang, S. J., & Le, A. (2018). Non-hodgkin lymphoma metabolism. In Advances in Experimental Medicine and Biology (Vol. 1063, pp. 95–106). Springer New York LLC. https://doi.org/10.1007/978-3-319-77736-8_7

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