Spherical agglomeration of aminophylline crystals during reaction in liquid by the spherical crystallization technique

Abstract

Spherically agglomerated crystals of aminophylline were prepared directly during reaction in liquid by the “spherical crystallization” technique. Agitation of a mixture of chloroform, ethanol (or methanol) and water containing ethylenediami ne and theophylline yielded spherically agglomerated crystals, the size of which was determined by the agitation speed of the system and the water content in the mixture. © 1982, The Pharmaceutical Society of Japan. All rights reserved.