Role of Toona ciliate extract in diabetes against streptozotocin – nicotinamide induced diabetic rats

Abstract

The present study was carried out to investigate the antihyperglycemic activity of the leaves of Toona ciliata hydroalcoholic extract in streptozotocin-induced diabetic rats. In the present study, effect of oral administration of T. ciliata leaves extract (0.2, 0.4g/kg body wt.) for 15 days on the level of blood glucose, serum cholesterol, triglycerides, urea, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) in normal and streptozotocininduced diabetic rats were evaluated. Histology of liver, kidney and pancreas were also studied. A significant decrease in blood glucose, serum cholesterol and triglycerides levels while total protein and HDL-C level was found to be increased as compared with the diabetic control group. The histology study of the diabetic rats treated with T. ciliata extract showed the significant results by showing recovery almost near to normal rats. The extract of the plant leaves at both the doses (0.2, 0.4g/kg body wt.) showed prominent effect and the finding suggest that Toona ciliata has significant antihyperglycemic activity in streptozotocin induced diabetes in rats.