Pulse component modification detection in Spino cerebellar ataxia 2 using ICA

Abstract

Anomalies in the oculomotor system are well known symptoms in patients with severe Spino Cerebellar Ataxia 2 form of autosomal dominant cerebellar ataxias (ADCA), including the main parameters used to describe saccadic movements. Also a combination of a pulse and step components constitutes an accepted model of the saccadic generation system, In the present work, Independent Component Analysis (ICA) is used to separate both components, revealing a significant difference in the time of the pulse component to reach its maximum value. This result suggests its use in order to obtain a classification tool to diagnose this disease. Five electro-oculographic records of patients of SCA2 ataxia and five control subjects were processed with the ICA based algorithm with this objective. © 2011 Springer-Verlag.