Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode

Abstract

Abnormal concentrations of dopamine in extracellular fluid are associated with a variety of diseases, such as Parkinson's disease. It, therefore, plays a critical role in the quantitative analysis of dopamine in body fluids in the control of biological drugs as well as in the clinical diagnostic field. Poly (3,4-ethylenedioxythiophene)-(Poly(4-styrenesulfonate)) was successfully fabricated on the surface of the glassy carbon electrode by electrochemical method and used to determine dopamine. The oxidation peaks of dopamine had higher sensitivity at PEDOT-PSS modified electrode in phosphate buffer solution (PBS, pH 6.0). The electrocatalytic activity of the corresponding dopamine electrodes was investigated using cyclic voltammetry (CV) and indicated that PEDOT: PSS by electropolymerization modified had a much higher electrocatalytic oxidation activity for dopamine than any other method. The results obtained have shown that PEDOT: PSS is a promising candidate for the modification of electrode material used in electrochemical sensing and other electrocatalytic applications.