Antigen-specific immunity conferred by T lymphocytes is a result of complex molecular interactions at the immunological synapse. A variety of biomimetic approaches have been devised to artificially induce T cell activation either to study the T cell biology or to expand and prime the therapeutic T cell populations. Here we first briefly review the molecular and cellular, structural and phenotypical bases that are involved in T cell activation. The artificial methods for T cell activation are then discussed in two grand categories, the soluble (3D) and the surface-anchored (2D) platforms with their design parameters. With the growing number of successful adoptive T cell therapies, the spurring demands for effective and safe T cell expansion as well as precise control over resulting T cell functions and phenotypes warrant the extensions of engineering parameters in the development of novel methodologies for T cell activation.
CITATION STYLE
Roh, K. H. (2018). Artificial methods for T cell activation: Critical tools in T cell biology and T cell immunotherapy. In Advances in Experimental Medicine and Biology (Vol. 1064, pp. 207–219). Springer New York LLC. https://doi.org/10.1007/978-981-13-0445-3_13
Mendeley helps you to discover research relevant for your work.