Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy

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Abstract

Atomic force microscopy has been used to probe the surface nanostructures of severe acute respiratory syndrome coronavirus (SARS-CoV). Single crown-like virion was directly visualized and quantitative measurements of the dimensions for the structural proteins were provided. A corona of large, distinctive spikes in the envelope was measured after treatment with hydroxyoctanoic acid. High-resolution images revealed that the surface of each single SARS-CoV was surrounded with at least 15 spherical spikes having a diameter of 7.29 ± 0.73 nm, which is in close agreement with that of S glycoproteins earlier predicted through the genomes of SARS-CoV. This study represents the first direct characterization of the surface ultrastructures of SARS-CoV particles at the nanometre scale and offers new prospects for mapping viral surface properties. © 2005 Blackwell Publishing Ltd.

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Lin, S., Lee, C. K., Lee, S. Y., Kao, C. L., Lin, C. W., Wang, A. B., … Huang, L. S. (2005). Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy. Cellular Microbiology, 7(12), 1763–1770. https://doi.org/10.1111/j.1462-5822.2005.00593.x

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