POLA PENGGUNAAN OBAT UNTUK PENDERITAGAGAL GINJAL AKUT DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM PUSAT (RSUP) DR. SARDJITO YOGYAKARTA TAHUN 1997-2001

Abstract

α-Ketocarbonyl peptides were generated from peptide precursors on solid support via a metal-ion-catalyzed transamination. The reaction proceeded to completion within 2 h with glyoxylate as electrophile and copper(II) ions as catalyst in an aqueous acetate buffer at pH 5.5-6.0. The variety of naturally occurring α-amino acid substrates gave rise to a diverse set of differentially functionalized ketones. The highly reactive terminal ketocarbonyls were prone to aldol-type dimerization and could be transferred into stable moieties by oxime formation, reduction to the alcohol, or reductive amination, respectively. The α-ketocarbonyl peptides were efficient in nucleophilic addition of C-nucleophiles such as phosphono-ylides and allylsilanes.