We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 × 10-70), rs198358 (P = 8 × 10-30) and rs632793 (P = 2 × 10-10), and of plasma B-type natriuretic peptide with rs5068 (P = 3 × 10 -12), rs198358 (P = 1 × 10-25) and rs632793 (P = 2 × 10-68). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 × 10-6 and 6 × 10-5, respectively) and diastolic blood pressure (P = 1 × 10-6 and 5 × 10 -5), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 × 10-5; OR = 0.90, 95% CI = 0.85-0.95, P = 2 × 10-4, respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension. © 2009 Nature America, Inc. All rights reserved.
CITATION STYLE
Newton-Cheh, C., Larson, M. G., Vasan, R. S., Levy, D., Bloch, K. D., Surti, A., … Wang, T. J. (2009). Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nature Genetics, 41(3), 348–353. https://doi.org/10.1038/ng.328
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