A protocol for a visible-light-induced cleavage of thioacetals and thioketals using molecular iodine as a photocatalyst in combination with oxygen as the terminal oxidant is reported. The reaction proceeds with low catalyst loadings and high chemical yields while the most commonly used N- and O-protecting groups remain untouched in this transformation. Further investigation showed that the reaction also permits the synthesis of unsymmetrical disulfides by cleavage of unsymmetrical thioacetals.
CITATION STYLE
Krumb, M., Kammer, L. M., Forster, R., Grundke, C., & Opatz, T. (2020). Visible-Light-Induced Cleavage of C−S Bonds in Thioacetals and Thioketals with Iodine as a Photocatalyst. ChemPhotoChem, 4(2), 101–104. https://doi.org/10.1002/cptc.201900231
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