The impact of herpes zoster and post-herpetic neuralgia on quality of life: Patient-reported outcomes in six European countries

Abstract

Aim: To investigate the impact of an entire episode of herpes zoster (HZ) or post-herpetic neuralgia (PHN) on an individual's quality of life (QoL). Subjects and methods: Individuals aged ≥50 years with painful HZ in the previous 5 years were identified across six European countries (Spain, Portugal, The Netherlands, Belgium, Sweden and Switzerland). They participated in a survey comprising bespoke questions to evaluate their previous HZ/PHN episode. Results: A total of 1,005 individuals participated, 874 (87%) having had HZ, and 13% having had PHN. Generally, pain and QoL outcomes were similar irrespective of when HZ was diagnosed (≤12 versus 13-60 months) and age (50-59 versus ≥60 years). Mean pain scores were significantly higher in those with PHN versus HZ both on average (7.2 versus 6.4) and at worst (8.3 versus 7.4). PHN had a significantly higher impact on patients' perception of their overall QoL, with 37% reporting a high impact (HZ: 19%). Pain restrictions in the following QoL domains significantly impacted on the respondents' perception of QoL: enjoyment of life (level of impact, 31%), general activity (29%), mood (25%), sleep (8%) and walking ability (8%), and were significantly higher in those with PHN than in those with HZ. Sleep was the area worst affected. Conclusion: HZ, and particularly PHN, is associated with considerable levels of pain that have a significant impact on the QoL of participants across six European countries. © The Author(s) 2011. This article is published with open access at Springerlink.com.