Progress in thiol-ene/yne click chemistry

Abstract

Click chemistry has attracted great interests due to a wide variety of superior merits, including a wide range of applications, simplified experimental condition, rapid reaction speed, higher functional group conversion, environmental friendly and selectivity. And conception of click chemistry contributed to the synthetic chemistry apparently, in particular, with respect to pharmaceutical manufacture and biomedical materials, resulting in the most useful and promising synthetic method. Furthermore, thiol-ene/yne click chemistry, utilizing inclusion of visible light or UV light as catalytic medium, is a comparatively novel kind of click chemistry in comparison to several types of conventional reactions. In addition, the properties of the creative reaction stems from the combination the photoinitiated chemical reaction with the forementioned traditional click chemistry, providing a flexible approach to occur reaction within the oriented region and functional group. This review highlights the recent research on the preparation of functional polymeric microsphere, amphipathic block well-defined polymer, materials employed in the molecular device, desired dendritic polymers and chemistry modification via thiol-ene/yne click chemistry. Moreover, the problems and solutions are given for the future development of thiol-ene/yne click chemistry. © 2012 Chinese Chemical Society & SIOC, CAS.