Lack of association between juvenile myoclonic epilepsy and HLA-DR13

Abstract

Purpose: We sought to replicate and extend a previously reported positive association between juvenile myoclonic epilepsy and HLA-DR13. Methods: Ninety-three subjects with juvenile myoclonic epilepsy and 93 normal blood donors, entirely of white origin with their families mostly of French extraction, underwent DNA-based HLA-DR13 and DQB6 typing. Results: None of the investigated alleles or combination of alleles (DRB1*1301-DQB1*0603 or DRB1*1302-DQB1*0604) showed a significant difference between patients and controls. Conclusions: Unlike previously reported positive association, in this population, there is no evidence that susceptibility to juvenile myoclonic epilepsy is associated with HLA-DR13.