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Preparation of targeted anionic lipid-coated polyplexes for MicroRNA delivery

Humana Press Inc., (2016), 201-213
DOI: 10.1007/978-1-4939-3718-9_13
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Abstract

As nonviral nucleic acid delivery vehicles, lipid nanoparticles (LNPs) have been widely used. Here we describe the synthesis and evaluation of LNPs based on targeted anionic lipid-coated polyplexs for therapeutic delivery of microRNA (miRNA) mimics. These LNPs are particularly suited for therapeutic delivery of oligonucleotide agents to leukemia cells.

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Huang, X., Zhang, M., Wang, X., Lee, L. J., & Lee, R. J. (2016). Preparation of targeted anionic lipid-coated polyplexes for MicroRNA delivery. In Methods in Molecular Biology (Vol. 1445, pp. 201–213). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3718-9_13

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