A convenient method for the synthesis of nitrones by oxidation of N,N-disubstituted hydroxylamines with N-t-butylbenzenesulfinimidoyl chloride

Abstract

Various N,N-disubstituted hydroxylamines were smoothly oxidized to the corresponding nitrones under mild conditions (at -78 °C) by using N-t-butylbenzenesulfinimidoyl chloride and DBU in methylene chloride. Intermolecular 1,3-dipolar cycloaddition of thus formed nitrones with certain kinds of olefines was also performed by one-pot procedure.