A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 4 256 nmol mL-1 in vitro. The compound [2-ethyl-1-(4-pentoxy)phenyl-1H-imidazole] exhibited the most potent inhibitory activity. The MIC of this compound against S. aureus was found to be 8 nmol mL-1, smaller than that of the reference agents, ciprofloxacin and amoxicillin. Furthermore, the compound exhibited modest activity against several bacterial strains in a dose range of 8 256 nmol mL-1.
CITATION STYLE
Sun, X. Y., Liu, M. Y., Zhong, C. Y., Zheng, G. L., Lv, M. Y., Jing, B. T., … Wang, X. (2018). Synthesis and antibacterial evaluation of 2-ethyl-1-(4-substituted)phenyl- 1h-imidazole derivatives as open-chain analogues of 7-Alkoxyl-4,5-dihydro-imidazo[1,2-A]quinolines. Journal of the Brazilian Chemical Society, 29(4), 701–707. https://doi.org/10.21577/0103-5053.20170190
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