Manual vs automated 68Ga-radiolabelling—A comparison of optimized processes

Abstract

A critical factor for clinical practice is the production of 68Ga radiopharmaceuticals manufactured manually or through an automated procedure. 68Ga radiopharmaceuticals are often prepared manually, although this method can lead to an increased operator's radiation dose and potential variability within production. The present work compares 68Ga-radiolabelling (PSMA-11; DOTA-TOC) utilizing a cassette module (GAIA; Elysia-Raytest; Germany) with a manual setup for routine clinical production with regard to process reliability and reproducibility.