Dogsitescorer: A web server for automatic binding site prediction, analysis and druggability assessment

Abstract

Motivation: Many drug discovery projects fail because the underlying target is finally found to be undruggable. Progress in structure elucidation of proteins now opens up a route to automatic structure-based target assessment. DoGSiteScorer is a newly developed automatic tool combining pocket prediction, characterization and druggability estimation and is now available through a web server. © The Author 2012. Published by Oxford University Press. All rights reserved.