Danio rerio αe-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αe-catenin

Abstract

Background: Mammalian αE-catenin is an allosterically regulated F-actin binding protein that inhibits the Arp2/3 complex. Results: D. rerio αE-catenin is a monomer that binds β-catenin and F-actin simultaneously but does not inhibit the Arp2/3 complex. Conclusion: D. rerio αE-catenin directly links the cadherin-catenin complex to F-actin. Significance: Core functions but not regulatory properties are conserved between β-catenin orthologs. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.