There is a complex, dynamic, and bidirectional connection between autoimmunity and cancer. The underlying mechanisms of carcinogenesis and physiopathological aspects of autoimmune diseases are not fully understood. However, there is a common immunological base related to expression of autoantigens by tumour cells that cause an anti-cancer immune response, thereby, triggering the development of paraneoplastic rheumatic syndromes and autoimmune rheumatic diseases in a genetically predisposed population. The case is reported of a 57 year-old man presenting with pulmonary renal syndrome, and who was diagnosed lung cancer and systemic lupus erythematosus at the same time.
CITATION STYLE
Padilla-Ortiz, D., Sánchez-Esquivel, F., Londoño, J., Merayo-Chalico, J., Reyes-Martínez, V., Florez-Vargas, A., … Santos, A. M. (2020). Lung cancer acting as a trigger of autoimmunity: a medical challenge. Revista Colombiana de Reumatologia, 27(3), 218–223. https://doi.org/10.1016/j.rcreu.2019.10.004
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